advantages and disadvantages of pharmaceutical packaging materials

Therefore, glasss property of being highly non-reactive is incredibly beneficial to its use within pharmaceutical packaging. Type 1: ultra-resistant borosilicate glass. It provides great visibility towards your interior. Economical Your email address will not be published. increment pressure tester. Packaging has often been referred to as the 5th P of the marketing mix. The primary packaging systemis the material that first envelops the product and holds it i.e., those package components and subcomponents that actually come in contact with the product, or those that may have a direct effect on the product shelf-life e.g., ampoules and vials, prefilled syringes, IV containers, blister packs, Bottles, and Sachet packaging etc. Advantages and Disadvantages of Pharmaceutical Packaging Materials Customer convenience e.g. The drawback of using plastic, rather than glass, is the possibility of plastic materials interacting with the product by means of transferring leachables. Advantages: Light, air and moisture resistant Stable at high and low temperature Non-toxic & odorless Disadvantages Easily dented and scratched Comparatively expensive PVC Foil Advantages: Inexpensive Light weight Ease of thermoforming Air proof Disadvantages: Poor heat stabile Poor barrier against moisture ingress PVDC Foil Advantages: They are similar to glass syringes in terms of their functional properties such as break loose and gliding forces. The valves are set in an aluminum over seal. Blow & Blow process: In this parison is formed by compressed air. Glass or PlasticA Question of Use - PharmTech forming the final set of seals. Pharmaceuticals are a billion dollar industry in the United States. Most of these are made of aluminum . The advantages and disadvantages of vials made of tubing or blown glass regarding their application in freeze-drying will be discussed in the following section. Disadvantages It is used to pack liquids, food, chemicals . This way the customer can receive identically packaged sterile injection vials from two different manufacturers, which enables them to start filling the vials straight away without the need for any intermediate process steps., Glass and plastic complement each other with their specific properties and benefits, notes Friis. If you are looking for high quality and safe packaging for your drugs, we are always here to help you out and make your product packaging more effective and safer for your consumers. Type I Borosilicate GlassType II Treated Soda-Lime GlassType III Soda-Lime GlassType NP General Purpose Soda-Lime Glass. Drop your Inquiry! The use of glass in pharmaceutical packaging has many benefits. PHARMACEUTICAL PACKAGING colours of red/bluegreater intensities of strain are indicated by colours Revolving drum test, MATERIALS USED FOR Advantages of Pharmaceutical Packaging | Consolidated Strategy Group The highly shatter-resistant vials are durable and free of cosmetic defects. Packaging of pharmaceuticals, glass, plastic, rubber , metal as a container, the science, art and technology of It should not react with the contents stored in it. General Composition of Glass? Advantages: Oil resistant. Why not get in touch with our expert team today and find out how your packaging could be revolutionised. shape is achieved by one pressing of glass which is entrapped & This is the cooking process.. We constantly adapt our production processes to meet increasingly stringent market requirements, he adds. Product Promotion:- Packaging is also used for Essentially chemically inert, impermeable, strong and rigid. concave base with variety of neck finishes in various Plastics constitute about 20 % of weight of all pharmaceutical packaging. In drawing , molten glass is pulled through dies or rollers that Bottling is also easier for coding identification purposes. Type IITreated soda lime glass Vials They are relatively cheaper compared to other synthetic rubbers. These materials are commonly used in the pharmaceutical industry as closures for glass and/or plastic containers, small cases as one time used for methanol cones, protective. cavity of metal mold. Alumina (Al2O3) 1.75 % (approx) Disadvantages It is a very expensive material. Ex. It has been suggested that contamination of pharmaceutical products with BPA can negatively affect the brain and blood pressure. Basically, plastics containers consist of organic materials whose molecules have high molar masses and are composed of a large number of repeating relatively small units referred to as monomers. The individual packaging allows the medications to be stored and opened separately, thus preserving the contents of the package and making them more effective. 5. Annealing lehr The best blister packaging techniques are just one of the forms of vial pharmaceutical packaging available. of the closure has a tear away strip. These are all advantages when exploring materials for pharmaceutical packaging. Required fields are marked *. The high melting point of glass is due to the presence of silica. Another benefit of using glass in pharmaceutical packaging is that it does not leak like certain types of plastic (which can leak a chemical called Bisphenol A or BPA). Materials for packaging: advantages and disadvantages. This helps to: To put things bluntly, there is no one-size-fits-all approach when it comes to pharmaceutical packaging. The Pros and Cons of Paper Packaging SmartSolve It has been suggested that contamination of pharmaceutical products with BPA can negatively affect the brain and blood pressure. shaped between mould walls & plunger. Type 3: regular soda-lime glass. cooling. Owned and operated by AZoNetwork, 2000-2023. Aluminium oxide impacts chemical durability while magnesium oxide reduces the temperature required during moulding. formed in general. Most commonly used are tin, aluminium and lead. It is used to store topical products and oral dosage forms, Glass containers are mainly used in packaging liquid preparations due to their rigidity and their superior protective qualities. contents into molten glass. Primary packagings are those packages which are in direct contact with the Pharmaceutical formulation. Rubber is used in the pharmaceutical industry to make closures, cap liners and bulbs for dropper assemblies.The rubber polymers most commonly used are natural, neoprene and butyl rubber. process & is Impenetrable to moisture, oxygen and other gases, as well as micro-organisms and light, aluminium foil helps to keep medication in perfect condition for longer. Pharmaceutical packaging is divided into three parts, namely: primary, secondary, and tertiary systems of packaging [70 . ranging from white/orange through red/purple to green, yellow and white. It's Easy to Recycle. Glass bottles cost more than metal cans but offer good Reduced leaching action. Pharmaceutical packaging can be defined as the economical means of providing presentation, protection, identification . Current trends will likely shape the future of the industry, which is set to continue to show. While these are the most common types of pharmaceutical packaging available, there are many more on the market. Laboratory glass apparatus. These, if found in the plastic after polymerization are generally referred to as process residues. pressure. releasing the residual strain in the glass With internal linings, lead tubes are used for products such as chloride tooth Product Identification:- Packaging greatly helps in Packaging material is an important part of a pharmaceutical product. The bottom portion It can break with the blows. Acidity or alkalinity this test is carried out only when packaging systems are intended to contain a liquid formulation or a formulation that is dissolved in its container before use. Thanks to its superior barrier properties, aluminium foils remains the material of choice for pharma. Aluminium: Please use one of the following formats to cite this article in your essay, paper or report: Moore, Sarah. Do you have a review, update or anything you would like to add to this article? 2023 MJH Life Sciences and Pharmaceutical Technology. What is primary packaging pharmaceuticals? Blister packaging material is getting more popular as it provides an aseptic solution. Put simply, tertiary solutions are used to protect both the product and packaging that sits beneath it during transportation. pouches, Bottle seals, Tape seals, Breakable caps, Aerosol Our Duma tablet container, for example, is for solid active ingredients taken orally. Advantages: Lower weight, Thinner & more even wall control Hermitically sealed Tubular glass containers This combination makes it possible to enhance the vials oxygen-resistant properties many times over that of traditional COP monolayer vials. According to him, Gerresheimer produces plastic syringes in Germany for the ClearJect brand, which also uses COP. pharmaceutical products. 2. sealable flexible through heated crimping roller. Pharmaceutical Packaging: The Types & Benefits - Swiftpak Usually, this type of glass is only used to create packaging for products intended for oral or topical use. During heat sterilization, some types of glass containers have the tendency of shedding some part of the silica into the formulation. Weights & Measures Act Because they must be kept in a cool location, it can be difficult to transport the medications. The main aim of primary package is to protect the formulation from environmental, chemical, mechanical and/or other hazards. And then, there is still the question of how the medicine is to be bottled, he adds. 30, No. COP combines many of the properties of glass with the shatter-resistance of plastic, he points out. The strip of packets is cut into desired number of packets. PACKAGING OF PHARMACEUTICALS - pharmanotes.org The Gx Elite Vials have better quality as a result. Moore, Sarah. seal. or moist heat It is chemically resistance to most medicinal products. Advantages: Heat resistant. For this reason, there are few scientific publications that describe the available. Glass has been widely used as a drug packaging material. Glass containers are classified into Type I glass, Type II glass, Type III glass and Type IV glass based on their degree of chemical/hydrolytic resistance to water attack. Organic extractable total organic carbon. cooling & may give labeling & capacity problems. We can then dive into these types further and explore the products used within. The pharmaceutical industry has used glass to produce safe and secure packaging for its vast array of products for many decades. enclosing or protecting products for distribution, Benefits of Effective Pharmaceutical Packaging: Nowadays, there has been huge competition in every field. They used in packaging non-aqueous preparations and powders for parenteral use with the exception of freeze-dried preparations. water for a given time, then transferred to a cold water bath. For example, we have agreed with our competitor Nuova Ompi that we will use the same secondary packaging in the form of nests, trays, and tubs to package our Gx RTF vials-which is the well-known Ompi EZ-Fill packaging format. Autoclaving seal to the rim of the bottle in such a way that the product can The secondary packaging systemis outside the primary packaging and used to group primary packages together e.g., cartons, boxes, shipping containers, injection trays, etc. Annealing Process, carried out either manual or automatic. Seams Extreme conditions may cause deterioration, low temperatures leading to aqueous solutions freezing and, hence, to fracture of containers. filling station of the machine. Because of high M.P. and hold it. The primary distinction between graphene-based batteries and solid-state batteries lies in the composition of either electrode. With over 40 years experience, we have the knowledge and experience needed to recommend the very best solution for you. Glass is principally made up of silica (59-80%) with varying degree of calcium oxide (5-12 %) sodium oxide (12-17 %) aluminium oxide (0.5-3.0 %), barium oxide, boric oxide, potassium oxide, and magnesium oxide. sheet of glassine paper bounded together with wax or adhesive Paper/card boards Pharmaceutical designers and manufacturers are constantly debating what type of medical packaging is ideal. Pharmacist previous year question paper download. Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, Submission must include data on all packaging material constituents Scientists investigate the chance of potential reactions before deciding on the most appropriate packaging option. the risk lead poison . shape the soft glass. Green: iron oxide, manganese dioxide and chromium dioxide. The folded areas are sealed by pressing against a heated bar. End folded wrapper They are mostly available in orange and light brown color as these colors protect liquid drugs from ultraviolet lights. The amount of thermal The degree of protection required because of their light weight . Do not sell or share my personal information. Design provides a uniform wall section & avoid thick & thin areas. degree of barrier protection For medicine and pharmaceuticals, blister packaging can be completed with child safe features so only adults can open the packaging. than the inside, leaving the inner surface under a state of tension. We provide primary packaging for pharmaceutical products, food packaging, and stationery products. Get more information with just one click! Unpacking Precision Vaccines with Nicole Lewis (World Vaccine Conference 2023), Discussing Soft Mist Inhaler Technology with Marcel Baumann (World Vaccine Conference 2023). Silica (SiO2), Do not sell or share my personal information. A platform lead by pharmaceutical specialists to grow-up pharmaceutical professionals with scientific and technical knowledge. In recent years, the IoT is rapidly being introduced into almost all sectors, but it has particular importance in the EV industry. The container should not support mould growth. thermoplastic resin and vacuum drawing the soften sheet of plastic Features, Functions and selection of Pharmaceutical Packing Materials WILL DEPEND UPON: But there is a way to reap the rewards of aluminium foil, whilst reducing the . commonly used for the packaging of tablets and capsule . is coated on the surface of the inner seal as an encapsulated Small bottles will probably withstand a temperature differential of 6080C, and 1 Polyethylene Terephthalate: Uses, Advantages, and Disadvantages - Xometry Depending on the field of application, the pharmaceutical company may decide to use type I, type II, or type III glass, based on the hydrolytic resistance required, says Heymann, highlighting that Gerresheimers range extends from cough syrup bottles made from amber glass to sterile ready-to-fill (RTF) vials made from tubular glass designed for special injectables. The load is registered on a pressure gauge. Which is Better for Pharmaceutical Products: Glass or Plastic? Here we discuss how glass is used in pharmaceutical packaging and what benefits its use brings. Tin is the most chemically inert of all collapsible metal tubes . Butyl rubber, nitrile rubber is some synthetic rubbers used for the manufacturing of closures. Carboys: exist in balloon shape or cylindrical improve the design It is very fragile to the blows and that can hinder its transport. Temperatures of both baths are closely controlled. Facilitating the use of product:- Packaging should be Packaging should be such that it should maintain the integrity of the dosage form, should be inert in nature, should not be fragile, should have good mechanical strength. A sealing head is applied and the internal pressure These containers are small in size compared to the vials packaging and are mostly used to store single-dose medicines and are made up of glass or plastic materials. An optimised tertiary packaging solution should look to combine products as tightly and compact as possible, while using minimal materials and without causing strain or damage to products. Form excellent tamper-evident containers Disadvantages: They are expensive. So, what is pharmaceutical packaging, how its been done, does it have different types, what are the materials used? This secure form can make it difficult for some to open, especially those dealing with arthritis or other degenerative medical conditions. speed automatic filling operations. for dispensing records. Glass Defects, test Blister packs act as perfect sealing agents for microbes and provide stable and reliable solutions for pills. Fin seal wrapper It has high melting point so can with stand high temperatures. In January 2017, Gerresheimer announced the introduction of a new metal-free technology for residue-free cone shaping (2). There are exceptions to what weve mentioned above, and the rules are not set in stone - It all boils down to whats needed to best suit your product and business. to form in the cavity of mold. Its main use is for packaging of the industrial process. They can be easily labelled. https://www.azom.com/article.aspx?ArticleID=20059. Lead has the lowest cost of all tube metals and is widely used for non food submit data on packaging materials & components to FDA prior to formaldehyde (MF), Epoxy resins (epoxides), Polyurethanes (PURs) Unable to withstand sudden changes in temperature Although this is not a usually a problem, it can make things tricky for air sensitive medications, as the bottle is opened and closed multiple times throughout the day. Stippling of the base is useful in improving base grip, masking mould If the products have been treated with sulfites, aluminum is the material they need. These medications are constantly under clinical trial material supply for improvements. Alkalinity is removed by using boric oxide to neutralized the Alteration on the properties of plastics or product. Breakage risk can be avoided by adequate bottle https://citeseerx.ist.psu.edu/, Types of pharmaceutical packaging. Some std. Collapsible tubes used for packaging are constructed of metal, The selection of Packaging material is made on the basis of its efficacy and performance characteristics in preserving the quality, potency and safety of the pharmaceutical products. appearance. identification of products. The packaging of drugs is important to protect drugs from damage, germs, outer atmosphere, and bacteria and at the same time have to take care of child and old age safety concerns. interpretation of strain is frequently one of experience. When frozen, however, thermoplastics become glass-like and subject to fracture. of glass Blister packs are gaining popularity owing to their smart features; one can track whether the pills are taken on time or not. This is an untreated soda lime glass with average chemical resistance. It is categorizes into following types: They provide the same benefits of bottled medications, but solve the problem of storing air or temperature resistant medications. which, if missing, can reasonably be expected to provide Although the cathode is commonly changed, carbon allotropes can also be employed in fabricating anodes. Ceramic Printing 2. platform and a hydraulic ramp platform Advantages: Pharmaceutical products are composed of specific, calculated mixtures of molecules. Compatibility with the dosage form With Botox, Chesapeake VA Residents Can Look And Feel Better. Leaching of Alkali Annealing Point: The sp. Pharmaceutical packaging is mainly constructed of plastic or glass. Excellent aging characteristic. This type of glass packaging is similar to type 2 glass, although it has not been treated and, therefore, does not have enhanced chemical resistance. Heat resistance. iv. Used for non-parenteral products, those intended for oral or topical use. It is a fragile material. It is outer package of secondary packaging & prevents damage to the products. 6. Sterilization method to be employed and cost, been widely used as a drug packaging material e.g. Reusable & Recyclable Problems associated with controlled drug release systems . The use of CAD/CAM & computer technology is widely applied to Advantages shock a bottle will withstand depends on its size, design and glass distribution. reclosure, and adequate protection of the product. Decrease CO2 emissions. Packaging also refers to the process of design, The shrink wrap concept involves the packaging of the scars & improving strength of the container. formulation by the packaging material are referred to as "Sorption". Gerresheimers Gx Elite Vials, for example, are produced using a conversion process that has been optimized to design out the risk of flaws during production (1). 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